About   Help   FAQ
Targeted Allele Detail
Symbol: Krastm1(Hras)Rdl
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Roberto Di Lauro
MGI ID: MGI:3581451
Synonyms: HrasKI, Kras(Hras)
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:98940
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
Mutation detailsA cassette containing Hras1 cDNA and a neo was fused in-frame with exon 2 such that synthesis of any Kras product would be abolished. Kras protein was undetectable in mutants. Hras1 protein was demonstrated to be present in brain, heart, liver, lung and spinal cord of mutants. (J:98940)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  35 strains or lines available
Original:  J:98940 Potenza N, et al., Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep. 2005 May;6(5):432-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory