About   Help   FAQ
Krastm1(Hras)Rdl
Targeted Allele Detail
Nomenclature
Symbol: Krastm1(Hras)Rdl
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Roberto Di Lauro
MGI ID: MGI:3581451
Synonyms: HrasKI, Kras(Hras)
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98940
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA cassette containing Hras1 cDNA and a neo was fused in-frame with exon 2 such that synthesis of any Kras product would be abolished. Kras protein was undetectable in mutants. Hras1 protein was demonstrated to be present in brain, heart, liver, lung and spinal cord of mutants. (J:98940)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  35 strains or lines available
References
Original:  J:98940 Potenza N, et al., Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep. 2005 May;6(5):432-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/26/2019
MGI 6.14
The Jackson Laboratory