Cd14^hdl
Chemically induced Allele Detail

Summary

• Symbol: Cd14^hdl
• Name: CD14 antigen; heedless
• MGI ID: MGI:3581425
• Synonyms: Cd14^m1Btlr, hdl
• Gene: Cd14 Location: Chr18:36858120-36859851 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Cd14^hdl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Nucleotide substitutions
• Mutation details: RT-PCR and sequencing revealed a premature stop codon caused by a Q248X substitution. This mutation putatively results in the loss of the 83 C-terminal amino acids polypeptide chain. (J:98908)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd14 Mutation: 23 strains or lines available

References

• Original: J:98908 Jiang Z, et al., CD14 is required for MyD88-independent LPS signaling. Nat Immunol. 2005 Jun;6(6):565-70
• All: 7 reference(s)