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Cox7a1tm1Hutt
Targeted Allele Detail
Summary
Symbol: Cox7a1tm1Hutt
Name: cytochrome c oxidase subunit 7A1; targeted mutation 1, Maik Huttemann
MGI ID: MGI:3580679
Gene: Cox7a1  Location: Chr7:29883596-29885455 bp, + strand  Genetic Position: Chr7, 17.31 cM
Alliance: Cox7a1tm1Hutt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192141
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll three exons were replaced with a neo cassette. QRT-PCR confirmed the absence of transcript expression. (J:192141)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cox7a1 Mutation:  7 strains or lines available
References
Original:  J:192141 Huttemann M, et al., Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy. Mitochondrion. 2012 Mar;12(2):294-304
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory