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Hrastm1Grnt
Targeted Allele Detail
Nomenclature
Symbol: Hrastm1Grnt
Name: Harvey rat sarcoma virus oncogene; targeted mutation 1, Seth G N Grant
MGI ID: MGI:3580632
Synonyms: H-Ras-
Gene: Hras  Location: Chr7:141189105-141194005 bp, - strand  Genetic Position: Chr7, 86.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98903
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a TAG3-IRES-Betageo-pa with stop codons in all reading frames into exon 4. Immunoblot demonstrated absence of protein in mutants. (J:98903)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hras Mutation:  20 strains or lines available
References
Original:  J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory