Nsila9^A/J
QTL Variant Detail

Summary

• QTL variant: Nsila9^A/J
• Name: novelty/stress induced locomotor activation 9; A/J
• MGI ID: MGI:3580575
• QTL: Nsila9 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

The allele effect at Nsila9 depends on genetic background and the type of cross. The A/J-derived allele is associated with increased locomotor activation in the AcB population whereas the C57BL/6J-derived allele is associated with increased locomotor activation in the AXB/BXA RI population.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:98477

QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.

On mouse Chromosome 13 linkage to locomotor activation in a novel environment was detected at 47 cM near D13Mit110. This locus is designated Nsila9 (novelty/stress induced locomotor activation 9). The A/J-derived allele is associated with increased locomotor activation in the AcB population whereas the C57BL/6J-derived allele is associated with increased locomotor activation in the AXB/BXA RI population. A potential candidate gene mapping near this locus is Crhbp (52cM).

References

• Original: J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• All: 1 reference(s)