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Nsila7A/J
QTL Variant Detail
Summary
QTL variant: Nsila7A/J
Name: novelty/stress induced locomotor activation 7; A/J
MGI ID: MGI:3580571
QTL: Nsila7  Location: unknown  Genetic Position: Chr8, cM position of peak correlated region/allele: 63.1 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  A/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased locomotor activation in a novel environment compared to C57BL/6J. (J:98477)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:98477

QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.

In the AXB/BXA RI population, a locus at 37 cM on mouse Chromosome 8 near D8Mit305 (LOD=3.84) showed significant linkage to locomotor activation in a novel environment. The interval between D8Mit132 (33 cM) and D8Mit305 (37 cM) showed maximum linkage (LOD=4.1) to the phenotype. This locus is designated Nsila6 (novelty/stress induced locomotor activation 6). The C57BL/6J-derived allele at Nsila6 is associated with increased novelty/stress induced activation of locomotor activity. Nsila6 shows interaction with a locus on mouse Chromosome 6 at 3.3 cM near D6Mit50, which is most likely the same locus as Nsila5. Animals homozygous for C57BL/6J-derived alleles at both Nsila6 and Nsila5 exhibit the greatest locomotor activation in a novel environment.

In the AcB/BcA RC population, a locus at 59 cM on mouse Chromosome 8 near D8Mit186 showed significant linkage to locomotor activation in a novel environment. The QTL interval spans 47 cM - 73 cM. This locus is designated Nsila7 (novelty/stress induced locomotor activation 7). The A/J-derived allele at Nsila7 is associated with increased novelty/stress induced activation of locomotor activity. A previously identified stress-related QTL mapping near Nsila7 is Siafq1 (56 cM).

References
Original:  J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory