Tg(Tyr-cre)3Gfk
Transgene Detail

Summary

• Symbol: Tg(Tyr-cre)3Gfk
• Name: transgene insertion 3, Graham F Kay
• MGI ID: MGI:3580525
• Synonyms: TEC3, TgN(TyrCre)3Gfk
• Transgene: Tg(Tyr-cre)3Gfk Location: unknown
• Alliance: Tg(Tyr-cre)3Gfk page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2 or (C57BL/6 x 129)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tyr-cre)3Gfk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tyr

• Mutation details: These transgenes express cre under the control of the tyrosinase promoter. Three lines were reported. Lines 1 and 2 include the full enhancer in addition to the promoter. Line 3 lacks the enhancer. Line 3 expresses cre solely in melanoblasts. (J:87271)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tyr (species not specified) Summary of all recombinase alleles driven by Tyr. Comparative matrix view of recombinase activities

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyr-cre)3Gfk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Strain of origin for these mtransgenes is either BCBF2 or B6129F2. They were subsequently backcrossed to C57BL/6 for maintainance.

References

• Original: J:87271 Tonks ID, et al., Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues. Genesis. 2003 Nov;37(3):131-8
• All: 5 reference(s)