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Chrm1tm1Kano
Targeted Allele Detail
Summary
Symbol: Chrm1tm1Kano
Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Masanobu Kano
MGI ID: MGI:3580391
Synonyms: M1-
Gene: Chrm1  Location: Chr19:8641369-8660970 bp, + strand  Genetic Position: Chr19, 5.44 cM
Alliance: Chrm1tm1Kano page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98902
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo selection cassette replaced a fragment containing the 5' flanking sequence and initiation codon. (J:98902)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm1 Mutation:  26 strains or lines available
References
Original:  J:98902 Ohno-Shosaku T, et al., Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus. Eur J Neurosci. 2003 Jul;18(1):109-16
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory