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Frs2tm3Scl
Targeted Allele Detail
Nomenclature
Symbol: Frs2tm3Scl
Name: fibroblast growth factor receptor substrate 2; targeted mutation 3, J Schlessinger
MGI ID: MGI:3580390
Synonyms: Frs2a-
Gene: Frs2  Location: Chr10:117070129-117148474 bp, - strand  Genetic Position: Chr10, 65.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98901
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed such that a 0.5 kb fragment containing sequence encoding the first 22 amino acids, the first coding exon, was replaced by an IRES Beta-galactosidase neomycin resistance cassette. (J:98901)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frs2 Mutation:  50 strains or lines available
References
Original:  J:98901 Hadari YR, et al., Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8578-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory