About   Help   FAQ
Frs2tm3Scl
Targeted Allele Detail
Nomenclature
Symbol: Frs2tm3Scl
Name: fibroblast growth factor receptor substrate 2; targeted mutation 3, J Schlessinger
MGI ID: MGI:3580390
Synonyms: Frs2a-
Gene: Frs2  Location: Chr10:117070129-117148474 bp, - strand  Genetic Position: Chr10, 65.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98901
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed such that a 0.5 kb fragment containing sequence encoding the first 22 amino acids, the first coding exon, was replaced by an IRES Beta-galactosidase neomycin resistance cassette. (J:98901)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frs2 Mutation:  53 strains or lines available
References
Original:  J:98901 Hadari YR, et al., Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8578-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/20/2017
MGI 6.10
The Jackson Laboratory