Rgs4^tm1.1Jbr
Targeted Allele Detail

Summary

• Symbol: Rgs4^tm1.1Jbr
• Name: regulator of G-protein signaling 4; targeted mutation 1, Jean-Francois Brunet
• MGI ID: MGI:3580388
• Synonyms: Rgs4^lacZ
• Gene: Rgs4 Location: Chr1:169569046-169575211 bp, - strand Genetic Position: Chr1, 76.84 cM
• Alliance: Rgs4^tm1.1Jbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98888
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed such that a lacZ and an FRT-flanked neo was inserted downstream of the 3' UTR. Cre mediated recombination removed exons 3-5, creating an in-frame fusion with the lacZ reporter. In situ hybridization was unable to detect Rgs4 expression. (J:98888)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs4 Mutation: 18 strains or lines available

References

• Original: J:98888 Grillet N, et al., Generation and characterization of Rgs4 mutant mice. Mol Cell Biol. 2005 May;25(10):4221-8
• All: 2 reference(s)