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QTL Variant Detail
QTL variant: Idd16.1ALR/LtJ
Name: insulin dependent diabetes susceptibility 16.1; ALR/LtJ
MGI ID: MGI:3579888
QTL: Idd16.1  Location: unknown  Genetic Position: Chr17, Syntenic
Strain of Specimen:  ALR/LtJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to type I diabetes mellitus compared to NOD/LtJ. (J:98187)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
This allele confers slower insulitis progression.

Mapping and Phenotype information for this QTL, its variants and associated markers


Analysis of interval specific congenic lines resolved the Idd16 diabetes QTL into two distinct loci named Idd16a and Idd16b. ALR/LtJ-derived portions of the Idd16 locus were introgressed onto the genetic background of NOD/LtJ. Parental strain ALR/LtJ is resistant to insulin-dependent (type 1) diabetes whereas parental strain NOD/LtJ is susceptible. Three different subcongenic lines were contructed.

Idd16a is localized to the distal portion of the original Idd16 QTL interval between D17Mit13 (19.06 cM) and H2-D (19.09 cM). The ALR/LtJ-derived allele of Idd16a appears to slow insulitis progression, but not its prevention. Potential candidate genes for Idd16a are Tnf (19.06 cM) and H2-Ddx (19 cM). The latter is considered a stronger candidate gene since serum levels of Tnf do not differ between NOD/LtJ and ALR/LtJ. The H2-Ddx allele is thought to be involved in resistance to type 1 diabetes.

Idd16b is localized to the proximal portion of the original Idd16 QTL interval above D17Mit16. Idd16b is involved in resistance to diabetogenesis.

Original:  J:98187 Pomerleau DP, et al., Major Histocompatibility Complex-Linked Diabetes Susceptibility in NOD/Lt Mice: Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2g7 Complex. Diabetes. 2005 May;54(5):1603-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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