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Targeted Allele Detail
Symbol: Tbx20tm1.1Rph
Name: T-box 20; targeted mutation 1.1, Richard P Harvey
MGI ID: MGI:3579836
Synonyms: Tbx20-, Tbx20lacZ
Gene: Tbx20  Location: Chr9:24632108-24685599 bp, - strand  Genetic Position: Chr9, 10.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:98489
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination resulted in the excision of the coding sequence in exons 1-3, and the placement of a lacZ reporter gene into endogenous cis-regulatory elements. RT-PCR confirmed absence of exons 1-3 and preservation of exons 4-6. (J:98489)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx20 Mutation:  24 strains or lines available
Original:  J:98489 Stennard FA, et al., Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May;132(10):2451-62
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory