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Pram1tm1Gak
Targeted Allele Detail
Nomenclature
Symbol: Pram1tm1Gak
Name: PML-RAR alpha-regulated adaptor molecule 1; targeted mutation 1, Gary A Koretzky
MGI ID: MGI:3579812
Synonyms: PRAM-1-
Gene: Pram1  Location: Chr17:33638056-33645706 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95253
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the start codon and 1,000 bp of the second coding exon. Immunoprecipitation and Western blot failed to detect protein in mutant bone marrow cell lysates. (J:95253)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pram1 Mutation:  23 strains or lines available
References
Original:  J:95253 Clemens RA, et al., PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol. 2004 Dec;24(24):10923-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory