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Kcptm1Gdr
Targeted Allele Detail
Nomenclature
Symbol: Kcptm1Gdr
Name: kielin/chordin-like protein; targeted mutation 1, Gregory R Dressler
MGI ID: MGI:3579811
Synonyms: Kcp-
Gene: Kcp  Location: Chr6:29473162-29507952 bp, - strand  Genetic Position: Chr6, 12.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97529
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-21, encoding amino acids 67-774, were replaced with a lacZ-neomycin cassette. Absence of transcript in mutants was confirmed by Northern blot and RT-PCR. (J:97529)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcp Mutation:  30 strains or lines available
References
Original:  J:97529 Lin J, et al., Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005 Apr;11(4):387-93
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory