Slf1^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Slf1^tm1Brd
• Name: SMC5-SMC6 complex localization factor 1; targeted mutation 1, Allan Bradley
• MGI ID: MGI:3579563
• Synonyms: Brctx^-
• Gene: Slf1 Location: Chr13:77191207-77283592 bp, - strand Genetic Position: Chr13, 40.98 cM, cytoband C1
• Alliance: Slf1^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96002
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The BRCT domain, encoded by exons 2 and 3, was replaced with a PGK-neo selection cassette. RT-PCR of mutant testis demonstrated the presence of a truncated transcript formed by the fusion of the 5' UTR in exon 1 to exon 5. (J:96002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slf1 Mutation: 65 strains or lines available

References

• Original: J:96002 Adams DJ, et al., BRCTx is a novel, highly conserved RAD18-interacting protein. Mol Cell Biol. 2005 Jan;25(2):779-88
• All: 1 reference(s)