Axin2^tm1Wbm
Targeted Allele Detail

Summary

• Symbol: Axin2^tm1Wbm
• Name: axin 2; targeted mutation 1, Walter Birchmeier
• MGI ID: MGI:3579503
• Synonyms: Ax2-, Axin2^-, Axin2^lacZ, Axin2^lacZki, Axin2^NLSlacZ, Axin2^tm1Jbeh, Axin2^tm1Mdcb, conductin^lacZ, Conductin^lz
• Gene: Axin2 Location: Chr11:108811175-108841609 bp, + strand Genetic Position: Chr11, 71.83 cM
• Alliance: Axin2^tm1Wbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74286
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene containing a nuclear localization signal was introduced in frame to the endogenous start codon by homologous recombination, thereby replacing most of exon 2. Beta-galactosidase staining reflected endogenous gene expression in the developing embryo. (J:74286)

Disease models

Expression

In Mice Carrying this Mutation:	261 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Axin2 Mutation: 43 strains or lines available

References

• Original: J:74286 Lustig B, et al., Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol. 2002 Feb;22(4):1184-93
• All: 184 reference(s)