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Targeted Allele Detail
Symbol: Axin2tm1Wbm
Name: axin2; targeted mutation 1, Walter Birchmeier
MGI ID: MGI:3579503
Synonyms: Ax2-, Axin2-, Axin2lacZ, Axin2lacZki, Axin2NLSlacZ, Axin2tm1Jbeh, conductinlacZ, Conductinlz
Gene: Axin2  Location: Chr11:108920349-108950783 bp, + strand  Genetic Position: Chr11, 71.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:74286
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ gene containing a nuclear localization signal was introduced in frame to the endogenous start codon by homologous recombination, thereby replacing most of exon 2. Beta-galactosidase staining reflected endogenous gene expression in the developing embryo. (J:74286)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 106 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Axin2 Mutation:  7 strains or lines available
Phenotypic Similarity to Human Syndrome: Craniosynostosis in homozygous mice (J:98523)

Original:  J:74286 Lustig B, et al., Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol. 2002 Feb;22(4):1184-93
All:  82 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory