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Stk11tm1Keis
Targeted Allele Detail
Nomenclature
Symbol: Stk11tm1Keis
Name: serine/threonine kinase 11; targeted mutation 1, Kei Sakamoto
MGI ID: MGI:3579498
Synonyms: LKB1fl
Gene: Stk11  Location: Chr10:80115803-80130682 bp, + strand  Genetic Position: Chr10, 39.72 cM
Urothelial hyperplasia and increased apoptosis in bladder epithelium of Ptentm2Mak/Ptentm2Mak Stk11tm1Keis/Stk11tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98513
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  6 strains or lines available
References
Original:  J:98513 Sakamoto K, et al., Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 2005 May 18;24(10):1810-20
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory