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Fkbp4tm1Dvds
Targeted Allele Detail
Nomenclature
Symbol: Fkbp4tm1Dvds
Name: FK506 binding protein 4; targeted mutation 1, David F Smith
MGI ID: MGI:3579432
Synonyms: 52KO, Fkbp52-
Gene: Fkbp4  Location: Chr6:128430103-128438656 bp, - strand  Genetic Position: Chr6, 63.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98554
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced the entire coding sequence. Western blot failed to detect protein in thymic cytosol of mutants. (J:98554)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fkbp4 Mutation:  15 strains or lines available
References
Original:  J:98554 Cheung-Flynn J, et al., Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol Endocrinol. 2005 Jun;19(6):1654-66
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory