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Park7tm1Shn
Targeted Allele Detail
Nomenclature
Symbol: Park7tm1Shn
Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Jie Shen
MGI ID: MGI:3579140
Synonyms: DJ-1-
Gene: Park7  Location: Chr4:150897133-150914437 bp, - strand  Genetic Position: Chr4, 81.52 cM, cytoband E1
Characterization of Park7tm1Shn/Park7tm1Shn mice

Show the 1 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98436
Parent Cell Line:  MKV6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129)F1
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
    Exon 2 was replaced with a pgk-neo cassette. Western blot failed to detect protein in mutant mice. (J:98436)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Park7 Mutation:  40 strains or lines available
References
Original:  J:98436 Goldberg MS, et al., Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 2005 Feb 17;45(4):489-96
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory