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Tg(Ins2-TFRC/OVA)296Wehi
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-TFRC/OVA)296Wehi
Name: transgene insertion 296, Walter and Eliza Hall Institute of Medical Research
MGI ID: MGI:3578729
Synonyms: RIP-mOVA
Transgene: Tg(Ins2-TFRC/OVA)296Wehi  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Ovalbumin (OV) is present at high levels in pancreatic beta cells and in kidney proximal tubule cells and at very low levels in testes of transgenic mice. No OV has been detected immunohistologically in any of multiple other tissues examined. Mice expressing both this transgene and Tg(Tcra,Tcrb)1100Mjb (OT-1), which encodes an OV-specific T cell receptor expressed on CD8+ T lymphocytes, exhibit thymic deletion of OT-1 T cells, indicating presence of OV at very low levels in the thymus. Western blot analysis reproducibly measured the pancreatic islet OV content as 2.2 ng/ug of protein.

References
Original:  J:98589 Kurts C, et al., Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med. 1996 Sep 1;184(3):923-30
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory