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Abcg2tm1Bsor
Targeted Allele Detail
Nomenclature
Symbol: Abcg2tm1Bsor
Name: ATP-binding cassette, sub-family G (WHITE), member 2; targeted mutation 1, Brian P Sorrentino
MGI ID: MGI:3578727
Synonyms: Abcg2-, Bcrp1-
Gene: Abcg2  Location: Chr6:58584523-58695676 bp, + strand  Genetic Position: Chr6, 27.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82049
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3, containing the Walker A motif, and 4 were replaced with a neo. Mutants were demonstrated to lack protein in immunoblots of kidney and liver tissue lysates. (J:82049)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcg2 Mutation:  54 strains or lines available
References
Original:  J:82049 Zhou S, et al., Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12339-44
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory