About   Help   FAQ
Targeted Allele Detail
Symbol: Celsr3tm1Agof
Name: cadherin, EGF LAG seven-pass G-type receptor 3; targeted mutation 1, Andre M Goffinet
MGI ID: MGI:3578665
Gene: Celsr3  Location: Chr9:108826320-108852969 bp, + strand  Genetic Position: Chr9, 59.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:98367
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector was designed to delete exons 19-27. Transcript levels were two- to fourfold lower in mutants than in wild-type animals. RT-PCR confirmed deletion of exons 19-27. A cryptic splice acceptor site in modified intron 27 resulted in an 87-nt 5' extension of exon 28. The resulting protein lacks the GPS, 7TM and C-terminal cytoplasmic sequences. (J:98367)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Celsr3 Mutation:  57 strains or lines available
Original:  J:98367 Tissir F, et al., Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci. 2005 Apr;8(4):451-7
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory