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Targeted Allele Detail
Symbol: Notch3tm1Khan
Name: notch 3; targeted mutation 1, Kazunori Hanaoka
MGI ID: MGI:3578622
Synonyms: Notch3m
Gene: Notch3  Location: Chr17:32120820-32166880 bp, - strand  Genetic Position: Chr17, 17.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:98284
Parent Cell Line:  TT2F (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 4 was disrupted by the insertion of a neomycin resistance gene. Exon 4 encodes part of the extracellular domain. Northern blot revealed a transcript shorter than wild-type. 5' RACE experiments revealed that the start site for this short transcript was 23bp downstream of the neo in exon 4. Western blot analysis using antibodies raised against the intracellular domain indicated that the allele is a null. (J:98284)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch3 Mutation:  58 strains or lines available
Original:  J:98284 Kitamoto T, et al., Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1154-62
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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