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Targeted Allele Detail
Symbol: Pou5f1tm1Scho
Name: POU domain, class 5, transcription factor 1; targeted mutation 1, Hans R Shoeler
MGI ID: MGI:3578312
Synonyms: Oct4flox
Gene: Pou5f1  Location: Chr17:35506018-35510772 bp, + strand  Genetic Position: Chr17, 18.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:95317
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsOne loxP site was inserted upstream of exon1 and the essential promoter. A floxed neo cassette was inserted into intron 1. The selection cassette was excised by subsequent transient transcription of Cre recombinase in the ES cells. Northern blot analysis demonstrated that a normal sized transcript was expressed from this allele. (J:95317)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou5f1 Mutation:  72 strains or lines available
Original:  J:95317 Kehler J, et al., Oct4 is required for primordial germ cell survival. EMBO Rep. 2004 Nov;5(11):1078-83
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory