Rock1tm1Sna
Targeted Allele Detail
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Symbol: |
Rock1tm1Sna |
Name: |
Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, Shuh Narumiya |
MGI ID: |
MGI:3578223 |
Synonyms: |
rock-, ROCK-I- |
Gene: |
Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
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Alliance: |
Rock1tm1Sna page
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Eyes open at birth and omphalocele phenotypes of Rock1tm1Sna/Rock1tm1Sna mice
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:98250
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Beta-galactosidase and neomycin resistance genes replaced exons 3 and 4, which encode part of the kinase domain. Absence of protein was confirmed by immunoblot of whole-brain lysates of mutants.
(J:98250)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rock1 Mutation: |
57 strains or lines available
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Original: |
J:98250 Shimizu Y, et al., ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53 |
All: |
4 reference(s) |
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