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Rock1tm1Sna
Targeted Allele Detail
Nomenclature
Symbol: Rock1tm1Sna
Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, Shuh Narumiya
MGI ID: MGI:3578223
Synonyms: rock-, ROCK-I-
Gene: Rock1  Location: Chr18:10064401-10181792 bp, - strand  Genetic Position: Chr18, 4.91 cM, cytoband A2
Eyes open at birth and omphalocele phenotypes of Rock1tm1Sna/Rock1tm1Sna mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98250
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsBeta-galactosidase and neomycin resistance genes replaced exons 3 and 4, which encode part of the kinase domain. Absence of protein was confirmed by immunoblot of whole-brain lysates of mutants. (J:98250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rock1 Mutation:  8 strains or lines available
References
Original:  J:98250 Shimizu Y, et al., ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory