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Targeted Allele Detail
Symbol: Crebbptm1Pkb
Name: CREB binding protein; targeted mutation 1, Paul K Brindle
MGI ID: MGI:3578129
Synonyms: CBPKIX
Gene: Crebbp  Location: Chr16:3899198-4031864 bp, - strand  Genetic Position: Chr16, 2.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:98329
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
Mutation detailsA floxed neomycin selection cassette was inserted upstream of the exon encoding the KIX domain and the KIX containing exon itself was mutated so that the tyrosine at amino acid residue 650 became alanine, the alanine at residue 654 became glutamine and the tyrosine at residue 658 became alanine (Y650A, A654Q and Y658A). Transient cre expression then excised the selection cassette. Expression and stability of the mutated product were normal. (J:98329)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  72 strains or lines available
Original:  J:98329 Kasper LH, et al., A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 2002 Oct 17;419(6908):738-43
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory