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Ep300tm1Pkb
Targeted Allele Detail
Nomenclature
Symbol: Ep300tm1Pkb
Name: E1A binding protein p300; targeted mutation 1, Paul K Brindle
MGI ID: MGI:3578128
Synonyms: p300KIX
Gene: Ep300  Location: Chr15:81586214-81652077 bp, + strand  Genetic Position: Chr15, 38.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98329
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neomycin selection cassette was inserted upstream of the exon encoding the KIX domain and the KIX containing exon itself was mutated so that the tyrosine at amino acid residue 630 became alanine, the alanine at residue 634 became glutamine and the tyrosine at residue 638 became alanine (Y630A, A634Q and Y638A). Transient cre expression then excised the selection cassette. Expression and stability of the mutated product were normal. (J:98329)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ep300 Mutation:  62 strains or lines available
References
Original:  J:98329 Kasper LH, et al., A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 2002 Oct 17;419(6908):738-43
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory