Slc11a2^tm2Nca
Targeted Allele Detail

Summary

• Symbol: Slc11a2^tm2Nca
• Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; targeted mutation 2, Nancy C Andrews
• MGI ID: MGI:3577916
• Synonyms: Slc11a2^flox
• Gene: Slc11a2 Location: Chr15:100285779-100322090 bp, - strand Genetic Position: Chr15, 56.29 cM
• Alliance: Slc11a2^tm2Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98088
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 5 and a loxP flanked cytidine deaminase (CD)- neomycin cassette was inserted into intron 8. Transient cre expression removed the CD-neo cassette. (J:98088)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc11a2 Mutation: 38 strains or lines available

References

• Original: J:98088 Gunshin H, et al., Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest. 2005 May 2;115(5):1258-1266
• All: 12 reference(s)