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Slc11a2tm2Nca
Targeted Allele Detail
Nomenclature
Symbol: Slc11a2tm2Nca
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; targeted mutation 2, Nancy C Andrews
MGI ID: MGI:3577916
Synonyms: Slc11a2flox
Gene: Slc11a2  Location: Chr15:100285779-100322090 bp, - strand  Genetic Position: Chr15, 56.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98088
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted into intron 5 and a loxP flanked cytidine deaminase (CD)- neomycin cassette was inserted into intron 8. Transient cre expression removed the CD-neo cassette. (J:98088)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc11a2 Mutation:  31 strains or lines available
References
Original:  J:98088 Gunshin H, et al., Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest. 2005 May 2;115(5):1258-1266
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory