S1pr5^tm1Club
Targeted Allele Detail

Summary

• Symbol: S1pr5^tm1Club
• Name: sphingosine-1-phosphate receptor 5; targeted mutation 1, Catherine Lubetzki
• MGI ID: MGI:3577728
• Synonyms: Edg8/S1P5^-
• Gene: S1pr5 Location: Chr9:21154213-21159739 bp, - strand Genetic Position: Chr9, 7.75 cM, cytoband A4
• Alliance: S1pr5^tm1Club page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98099
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced by an IRES-lacZ. RT-PCR demonstrated loss of transcript in mutant brains. (J:98099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S1pr5 Mutation: 21 strains or lines available

References

• Original: J:98099 Jaillard C, et al., Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci. 2005 Feb 9;25(6):1459-69
• All: 7 reference(s)