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Targeted Allele Detail
Symbol: Mbl2tm1Kata
Name: mannose-binding lectin (protein C) 2; targeted mutation 1, Kazue Takahashi
MGI ID: MGI:3577339
Synonyms: MBL-C KO
Gene: Mbl2  Location: Chr19:30232928-30239685 bp, + strand  Genetic Position: Chr19, 25.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:98124
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by the insertion of a neomycin resistance gene into exon 6. RT-PCR analysis demonstrated the lack of transcript in mutant liver. (J:98124)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mbl2 Mutation:  3 strains or lines available
Original:  J:98124 Shi L, et al., Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med. 2004 May 17;199(10):1379-90
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory