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Targeted Allele Detail
Symbol: Dp(11Cops3-Rnf112)1Jrl
Name: duplication, Chr 11, James R Lupski 1
MGI ID: MGI:3577256
Synonyms: Dp(11)17, dup(11)(Csn3-Zfp179), dup(Csn3-Zfp179)
Gene: Dp(11Cops3-Rnf112)1Jrl  Location: Chr11:59817795-61454131 bp  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:83302
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutation:    Duplication
  Dp(11Cops3-Rnf112)1Jrl involves 77 genes/genome features (Gm16062, Cops3, Nt5m ...) View all
Mutation detailsThe engineered chromosome bears a duplication of a ~3 Mb segment of Chr 11 containing 19 genes including Cops3 (a.k.a. Csn3), which only in the duplicate copy is interrupted (and inactivated) by an insertion; the entire coding region, but not the final, untranslated exon of Rnf112 (formerly Zfp179); and all the intervening DNA. The insertion in Cops3 contains a tyrosinase minigene and a transgene comprising wild-type agouti cDNA under control of the human keratin 14 promoter. (J:83302)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(11Cops3-Rnf112)1Jrl Mutation:  1 strain or line available
Original:  J:83302 Walz K, et al., Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol. 2003 May;23(10):3646-55
All:  8 reference(s)

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MGI 6.11
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