Tg(Itgam-cre)AJva
Transgene Detail

Summary

• Symbol: Tg(Itgam-cre)AJva
• Name: transgene insertion A, Jean Vacher
• MGI ID: MGI:3577104
• Synonyms: Cd11b-Cre
• Transgene: Tg(Itgam-cre)AJva Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Itgam-cre)AJva page

Increase in cancellous bone mass in Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0 mice

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Itgam-cre)AJva expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Itgam

• Mutation details: Cre recombinase was placed under the control of the Itgam promoter. This line contained ~4 copies inserted into the Y chromosome and was expressed at significantly higher levels than line B in peritoneal macrophages. (J:97319)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Itgam (species not specified) Summary of all recombinase alleles driven by Itgam. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:97319 Ferron M, et al., Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice. Genesis. 2005 Mar;41(3):138-45
• All: 20 reference(s)