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Irf7tm1Ttg
Targeted Allele Detail
Nomenclature
Symbol: Irf7tm1Ttg
Name: interferon regulatory factor 7; targeted mutation 1, Tadatsugu Taniguchi
MGI ID: MGI:3577089
Synonyms: Irf7-
Gene: Irf7  Location: Chr7:141262706-141266481 bp, - strand  Genetic Position: Chr7, 86.57 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97662
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-betageo was inserted to replace exons 2 and 3. Northern and Western blot confirmed ablation of transcript and protein. (J:97662)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf7 Mutation:  9 strains or lines available
References
Original:  J:97662 Honda K, et al., IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005 Apr 7;434(7034):772-7
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory