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Tgif1tm1.1Caw
Targeted Allele Detail
Nomenclature
Symbol: Tgif1tm1.1Caw
Name: TGFB-induced factor homeobox 1; targeted mutation 1.1, Christopher A Walsh
MGI ID: MGI:3577049
Synonyms: Tgif-
Gene: Tgif1  Location: Chr17:70844205-70853546 bp, - strand  Genetic Position: Chr17, 41.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97642
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTgiftm1Caw mice were crossed with mice expressing cre in the germline to produce this allele in which exons 2 and 3 are deleted. Western blot demonstrated lack of protein in mutant embryos. (J:97642)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgif1 Mutation:  39 strains or lines available
References
Original:  J:97642 Shen J, et al., Targeted disruption of tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol. 2005 May;25(9):3639-47
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory