Acan^tm1Afos
Targeted Allele Detail

Summary

• Symbol: Acan^tm1Afos
• Name: aggrecan; targeted mutation 1, Amanda J Fosang
• MGI ID: MGI:3577026
• Synonyms: Chloe
• Gene: Acan Location: Chr7:78703231-78764847 bp, + strand Genetic Position: Chr7, 44.88 cM
• Alliance: Acan^tm1Afos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97622
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: In exon 7, the nucleotide sequence TTCTTCGGG was replaced with GGTACCCGG, changing the amino acids at position 342 from FFG to GTR to eliminate the MMP cleavage site. (J:97622)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acan Mutation: 77 strains or lines available

References

• Original: J:97622 Little CB, et al., Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Mol Cell Biol. 2005 Apr;25(8):3388-99
• All: 3 reference(s)