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Pcsk9tm1Jdh
Targeted Allele Detail
Nomenclature
Symbol: Pcsk9tm1Jdh
Name: proprotein convertase subtilisin/kexin type 9; targeted mutation 1, Jay D Horton
MGI ID: MGI:3577021
Synonyms: Pcsk9-
Gene: Pcsk9  Location: Chr4:106442329-106464329 bp, - strand  Genetic Position: Chr4, 49.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97836
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a neomycin resistance gene was inserted to replace the 3' half of exon 2 through exon 4. Northern blot of mutant livers confirmed absence of transcript. Immunoblot of livers further confirmed absence of protein. (J:97836)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pcsk9 Mutation:  6 strains or lines available
References
Original:  J:97836 Rashid S, et al., Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5374-9
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory