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Targeted Allele Detail
Symbol: Dicer1tm1Gz
Name: dicer 1, ribonuclease type III; targeted mutation 1, Genshi Zhao
MGI ID: MGI:3576927
Synonyms: Dicerex1/2
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Germline Transmission:  Earliest citation of germline transmission: J:97770
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a neomycin resistance gene to create this severely hypomorphic allele. Although a transcript from these two exons was not present in Northern blot analyses, a transcript originating from exon 3 was found. Western blot demonstrated the presence of a nonfunctional protein product probably originating from exon 4. (J:97770)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 16 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  52 strains or lines available
Original:  J:97770 Yang WJ, et al., Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005 Mar 11;280(10):9330-5
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory