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Birc2tm1Jda
Targeted Allele Detail
Nomenclature
Symbol: Birc2tm1Jda
Name: baculoviral IAP repeat-containing 2; targeted mutation 1, Jonathan D Ashwell
MGI ID: MGI:3576924
Synonyms: c-IAP1-
Gene: Birc2  Location: Chr9:7818227-7837063 bp, - strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97656
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced a portion of exon 1 containing the first baculovirus IAP repeat, the transcription start codon and sequences encoding the the first BIR domain. Immunoblot of mutant spleen and thymus whole cell lysates confirmed absence of protein. (J:97656)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Birc2 Mutation:  12 strains or lines available
References
Original:  J:97656 Conze DB, et al., Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol. 2005 Apr;25(8):3348-56
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory