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Targeted Allele Detail
Symbol: Pfkfb3tm1Jche
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; targeted mutation 1, Jason Chesney
MGI ID: MGI:3576782
Synonyms: iPFK2-
Gene: Pfkfb3  Location: Chr2:11471433-11554077 bp, - strand  Genetic Position: Chr2, 8.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:97595
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting construct was designed to insert a neomycin cassette and a stop codon to replace exons 3-7, the sequence encoding the substrate binding site and magnesium binding site. RT-PCR of heterozygote lung samples showed a 50% decrease in transcript levels. (J:97595)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pfkfb3 Mutation:  20 strains or lines available
Original:  J:97595 Chesney J, et al., Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality. Biochem Biophys Res Commun. 2005 May 27;331(1):139-46
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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