Psap^tm1Mhor
Targeted Allele Detail

Summary

• Symbol: Psap^tm1Mhor
• Name: prosaposin; targeted mutation 1, Mia Horowitz
• MGI ID: MGI:3576780
• Synonyms: Pro^delta8
• Gene: Psap Location: Chr10:60113449-60138376 bp, + strand Genetic Position: Chr10, 30.02 cM
• Alliance: Psap^tm1Mhor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97577
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A loxP-flanked PGK-neo replaced exon 8. The neo was removed by Cre mediated recombination. (J:97577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psap Mutation: 36 strains or lines available

References

• Original: J:97577 Cohen T, et al., The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion. Mol Cell Biol. 2005 Mar;25(6):2431-40
• All: 1 reference(s)