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Irf5tm1Ttg
Targeted Allele Detail
Nomenclature
Symbol: Irf5tm1Ttg
Name: interferon regulatory factor 5; targeted mutation 1, Tadatsugu Taniguchi
MGI ID: MGI:3576384
Synonyms: Irf5-
Gene: Irf5  Location: Chr6:29526625-29541871 bp, + strand  Genetic Position: Chr6, 12.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97567
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced sequence-encoding part of the DNA-binding domain in exon 2. Northern blot and immunoblot analyses confirmed absence of transcript and protein, in mutant MEFs and splenocytes, respectively. (J:97567)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf5 Mutation:  7 strains or lines available
Notes
Dock2mu was confirmed to be present in two Irf5tm1Ttg lines from the USA but not one line from Japan. J:182658
References
Original:  J:97567 Takaoka A, et al., Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature. 2005 Mar 10;434(7030):243-9
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory