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Targeted Allele Detail
Symbol: Gata6tm1Sad
Name: GATA binding protein 6; targeted mutation 1, Stephen A Duncan
MGI ID: MGI:3576383
Synonyms: Gata6-
Gene: Gata6  Location: Chr18:11052510-11085636 bp, + strand  Genetic Position: Chr18, 5.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:97579
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5 which encode the zinc finger domains of the encoded protein. In situ hybridization experiments on homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:97579)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata6 Mutation:  9 strains or lines available
The original reference (J:97579) used ES cell derived embryos only and did not indicate if a line of mice was generated for this allele
Original:  J:97579 Zhao R, et al., GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory