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Izumo1tm1Osb
Targeted Allele Detail
Nomenclature
Symbol: Izumo1tm1Osb
Name: izumo sperm-egg fusion 1; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:3576382
Synonyms: Izumo-, Izumo1tm1Oka
Gene: Izumo1  Location: Chr7:45621811-45627242 bp, + strand  Genetic Position: Chr7, 29.39 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97563
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene placed in the reverse orientation to transcription replaced exons 2-10. Mutants demonstrated lack of transcript and protein in Northern blot and Western blot analyses of testes and sperm, respectively. (J:97563)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Izumo1 Mutation:  17 strains or lines available
References
Original:  J:97563 Inoue N, et al., The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005 Mar 10;434(7030):234-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory