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Irs2tm1With
Targeted Allele Detail
Nomenclature
Symbol: Irs2tm1With
Name: insulin receptor substrate 2; targeted mutation 1, Dominic J Withers
MGI ID: MGI:3576079
Synonyms: Irs2lox
Gene: Irs2  Location: Chr8:10986961-11008430 bp, - strand  Genetic Position: Chr8, 5.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97406
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites were inserted to flank the coding region. (J:97406)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs2 Mutation:  16 strains or lines available
References
Original:  J:97406 Choudhury AI, et al., The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest. 2005 Apr 1;115(4):940-950
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory