Irs2^tm1With
Targeted Allele Detail

Summary

• Symbol: Irs2^tm1With
• Name: insulin receptor substrate 2; targeted mutation 1, Dominic J Withers
• MGI ID: MGI:3576079
• Synonyms: Irs2lox
• Gene: Irs2 Location: Chr8:11034681-11058458 bp, - strand Genetic Position: Chr8, 5.35 cM
• Alliance: Irs2^tm1With page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank the coding region. (J:97406)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs2 Mutation: 35 strains or lines available

References

• Original: J:97406 Choudhury AI, et al., The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest. 2005 Apr 1;115(4):940-950
• All: 6 reference(s)