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Tg(KRT5-rtTA)1Glk
Transgene Detail
Nomenclature
Symbol: Tg(KRT5-rtTA)1Glk
Name: transgene insertion 1, Adam Glick
MGI ID: MGI:3575756
Synonyms: BK5/rTA, K5/rTA, K5-rtTA
Transgene: Tg(KRT5-rtTA)1Glk  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
This is one of 11 lines generated using this transgenic construct. Of the 11, five lines were characterized for their effect on expression of a tetO-lacZ reporter gene in doubly transgenic mice. Such mice, when treated with doxycycline, exhibit 3- or 30-fold elevated levels of beta-galactosidase (b-gal) activity in skin relative to levels in tetO-lacZ singly-transgenic mice. Immunohistochemical staining for b-gal detects expression in skin and hair follicles, specifically in the outer root sheath of hair follicles and, in one line, the basal layer of the epidermis. Lower-level induction occurs in tongue, forestomach and trachea. No significant b-gal is detected in tissues that do not express endogenous keratin 5 or in the absence of doxycycline. (J:65791)

References
Original:  J:65791 Diamond I, et al., Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol. 2000 Nov;115(5):788-94
All:  22 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory