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Targeted Allele Detail
Symbol: P2rx7tm1Blo
Name: purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1, Barry R Bloom
MGI ID: MGI:3575425
Synonyms: GSK P2X7-, P2X7-
Gene: P2rx7  Location: Chr5:122643911-122691432 bp, + strand  Genetic Position: Chr5, 62.5 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:97422
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Modified isoform(s), Reporter)
Mutation:    Insertion
Mutation detailsThe targeting event results in the disruption of exon 1 by insertion of a LacZ gene (in-frame with the initiation codon) and neomycin selection cassette without deletion of any of the endogenous gene sequence. T cells in this strain retain high levels of P2X7 activity. The 13a isoform is expressed in these mice but no expression of the 13b or 13c isoforms is detected. (J:149750, J:194518)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P2rx7 Mutation:  15 strains or lines available
Original:  J:97422 Sikora A, et al., Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol. 1999 Jul 15;163(2):558-61
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory