Sipa1^tm1Nm
Targeted Allele Detail

Summary

• Symbol: Sipa1^tm1Nm
• Name: signal-induced proliferation associated gene 1; targeted mutation 1, Nagahiro Minato
• MGI ID: MGI:3575291
• Synonyms: SPA-1^-
• Gene: Sipa1 Location: Chr19:5701213-5713735 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Sipa1^tm1Nm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97239
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-8, which encode the GRD, were replaced with a neomycin resistance cassette. Mutant mice expressed no wild-type protein, as shown by immunoblot. (J:97239)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sipa1 Mutation: 37 strains or lines available

References

• Original: J:97239 Ishida D, et al., Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell. 2003 Jul;4(1):55-65
• All: 8 reference(s)