About   Help   FAQ
Sipa1tm1Nm
Targeted Allele Detail
Nomenclature
Symbol: Sipa1tm1Nm
Name: signal-induced proliferation associated gene 1; targeted mutation 1, Nagahiro Minato
MGI ID: MGI:3575291
Synonyms: SPA-1-
Gene: Sipa1  Location: Chr19:5651185-5663707 bp, - strand  Genetic Position: Chr19, 4.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97239
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 5-8, which encode the GRD, were replaced with a neomycin resistance cassette. Mutant mice expressed no wild-type protein, as shown by immunoblot. (J:97239)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sipa1 Mutation:  21 strains or lines available
References
Original:  J:97239 Ishida D, et al., Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell. 2003 Jul;4(1):55-65
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/15/2019
MGI 6.14
The Jackson Laboratory