Scarb1^Hlb398
Chemically induced Allele Detail

Summary

• Symbol: Scarb1^Hlb398
• Name: scavenger receptor class B, member 1; heart, lung and blood 398
• MGI ID: MGI:3575158
• Synonyms: Scarb1^I179N
• Gene: Scarb1 Location: Chr5:125354151-125418158 bp, - strand Genetic Position: Chr5, 64.11 cM
• Alliance: Scarb1^Hlb398 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion is located in exon 4 at 536 bp from the start site. This transversion results in a isoleucine to asparagine amino acid change. Western blot analysis indicates that protein expression in the liver of homozygous mice is reduced compared to wild-type controls but levels in the adrenals and ovaries are similar to wild-type controls. (J:152482)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scarb1 Mutation: 52 strains or lines available

References

• Original: J:82961 JAX National Heart, Lung and Blood Program for Genomic Applications (PGA), Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program. MGI Direct Data Submission. 2003-10
• All: 4 reference(s)