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Ltahlb382
Chemically induced Allele Detail
Nomenclature
Symbol: Ltahlb382
Name: lymphotoxin A; heart, lung and blood 382
MGI ID: MGI:3575123
Gene: Lta  Location: Chr17:35203165-35205351 bp, - strand  Genetic Position: Chr17, 18.59 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Insertion
 
Mutation detailsThis phenotypic mutant was identified in an ENU mutagenesis screen. An insertion of a cytosine occurred between nucleotides 16 and 17 of the second exon. This is predicted to cause a frameshift mutation from amino acid 6 and translation of a theoretical new peptide of 173 amino acids with a premature stop codon in exon 4. Because Ltb and Tnf are found in nearby genomic locations, their sequence and expression were analyzed and found to be normal. Intra-cell flow cytometry failed to detect any Lta expression in activated B-cells.
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lta Mutation:  7 strains or lines available
References
Original:  J:82961 JAX National Heart, Lung and Blood Program for Genomic Applications (PGA), Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program. MGI Direct Data Submission. 2003-10;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory