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Targeted Allele Detail
Symbol: Brsk1tm1Jrs
Name: BR serine/threonine kinase 1; targeted mutation 1, Joshua R Sanes
MGI ID: MGI:3575112
Synonyms: sadb-, SADB-
Gene: Brsk1  Location: Chr7:4693635-4718996 bp, + strand  Genetic Position: Chr7, 2.71 cM
Alliance: Brsk1tm1Jrs page
Germline Transmission:  Earliest citation of germline transmission: J:96030
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked neomycin resistance gene replaced the first coding exon. Northern blot of mutant brain samples demonstrated the lack of transcript. (J:96030)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Brsk1 Mutation:  41 strains or lines available
Original:  J:96030 Kishi M, et al., Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11;307(5711):929-32
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
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